Anti-TF/TOP1i Antibody-drug Conjugate XB371

**Semantic type:** Pharmacologic Substance

**Definition:** An antibody-drug conjugate (ADC) composed of a monoclonal antibody against human tissue factor (TF; F3; coagulation factor III; thromboplastin; CD142) conjugated, via a cleavable linker, to a cytotoxic DNA topoisomerase I inhibitor payload, with potential antiangiogenic and antineoplastic activities. Upon administration of anti-TF/TOP1i ADC XB371, the monoclonal antibody moiety targets and binds to TF expressed on tumor cells. After internalization and cleavage, the payload targets and binds to DNA topoisomerase I, thereby stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks, inhibition of DNA replication and induction of apoptosis. This inhibits the proliferation of TF-expressing tumor cells. In addition, XB371 induces a bystander effect, thereby further killing tumor cells. XB371 may also further induce anti-tumor immune responses. TF, a transmembrane protein and initiator of the coagulation cascade, is overexpressed in many tumor cells and tumor-resident endothelial cells. Expression of TF is correlated with metastasis, angiogenesis, tumor cell growth and tumor-associated thrombosis.

**Synonyms:** - Anti-TF ADC XB371 - Anti-TF Antibody-drug Conjugate XB371 - Anti-TF/TOP1i ADC XB371 - Anti-TF/Topoisomerase-1 Inhibitor Antibody-drug Conjugate XB371 - Anti-Tissue Factor ADC XB371 - TF-TOPOi ADC XB371 - XB 371 - XB-371 - XB371