Yttrium Y 90-NM600

**Semantic type:** Pharmacologic Substance

**Definition:** A radioconjugate composed of NM600, a tumor-selective alkylphosphocholine (APCh) analog, conjugated with the radioisotope yttrium 90 (Y-90), with potential antineoplastic activity. Upon administration of yttrium Y 90-NM600, NM600 is selectively taken up by tumor cells via membrane lipid rafts and accumulates in tumor cells. This allows for the specific delivery of a cytotoxic dose of beta radiation to tumor cells. Cancer cells have higher level of lipid rafts, which play an important role in cancer cell metastasis and cell death.

**Synonyms:** - 90Y-NM600 - Yttrium Y 90 NM600