Allogeneic TCR Alpha/Beta/CD19-positive Cell-depleted Peripheral Blood Mononuclear Cells

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of allogeneic peripheral blood mononuclear cells (PBMCs) that have been depleted of T-cell receptor (TCR) alpha and beta (TCRa/b+) as well as CD19-positive (CD19+) cells, that can potentially be used for immune reconstitution purposes. Upon administration, the allogeneic TCRa/b+/CD19+ cell-depleted PBMCs may allow for immune reconstitution. The depletion of TCRa/b+ T-cells may lower the risk of graft-versus-host disease (GvHD). The depletion of CD19+ cells may reduce the risk of post-transplant lymphoproliferative disorder (PTLD) as well as GvHD.

**Synonyms:** - Allogeneic TCR Alpha/Beta/CD19-positive Cell-depleted PBMCs - Allogeneic TCRa/b+/CD19+ Cell-depleted PBMCs