Pan-KRAS Inhibitor TLN-372

**Semantic type:** Pharmacologic Substance

**Definition:** A small molecule inhibitor of KRAS mutations, with potential antineoplastic activity. Upon administration, pan-KRAS inhibitor TLN-372 targets, binds to and inhibits various forms of KRAS mutations, thereby inhibiting KRAS-dependent signaling. This inhibits the proliferation of and induces apoptosis in tumor cells in which KRAS is mutated. KRAS plays an important role in cell signaling, division and differentiation. Mutations of KRAS may induce constitutive signal transduction leading to tumor cell growth, proliferation, invasion, and metastasis.

**Synonyms:** - KRAS Inhibitor TLN-372 - TLN 372 - TLN-372 - TLN372