Anti-DLL3 Antibody-drug Conjugate BL-M14D1

**Semantic type:** Pharmacologic Substance

**Definition:** An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against the tumor-associated antigen (TAA) delta-like protein 3 (DLL3) conjugated, via a cathepsin-B cleavable linker, to the camptothecin derivative and topoisomerase 1 inhibitor Ed-04, with potential antineoplastic activity. Upon administration of anti-DLL3 ADC BL-M14D1, the monoclonal antibody moiety targets and binds to DLL3-expressing tumor cells. Upon binding and linker cleavage, Ed-04 is released and inhibits DNA topoisomerase I activity, thereby inhibiting DNA replication and resulting in cell cycle arrest and apoptosis in tumor cells expressing DLL3. DLL3, a Notch pathway protein, is overexpressed on a variety of cancer cell types. It plays a key role in embryonic development, tumor initiation and proliferation.

**Synonyms:** - Anti-DLL3 ADC BL-M14D1 - Anti-DLL3/Ed-04 ADC BL-M14D1 - Anti-DLL3/Ed-04 Antibody-drug Conjugate BL-M14D1 - Anti-DLL3/TOP1i ADC BL-M14D1 - BL M14D1 - BL-M14D1 - BLM14D1