RevM10 gene/polAS gene

**Semantic type:** Gene or Genome|Pharmacologic Substance

**Definition:** Retroviral based anti-HIV-1 transduction construct. RevM10, a dominant negative mutant of the HIV-1 Rev gene, abolishes the wild-type Rev function and inhibits viral replication in HIV-infected T cell lines and primary T cells in vivo. PolAS is an antisense RNA complementary to human HIV-1 pol gene and is capable of interfering with HIV polymerase gene expression. Co-administration of both gene constructs allows high efficiency in blocking propagation of HIV.