Carboxydextran-coated Superparamagnetic Iron Oxide Suspension

**Semantic type:** Indicator, Reagent, or Diagnostic Aid

**Definition:** An aqueous suspension formulation of carboxydextran-coated superparamagnetic iron oxide (SPIO), that can be used to localize lymph nodes draining a tumor site, as part of a sentinel lymph node biopsy (SLNB) procedure, in patients with breast cancer undergoing a mastectomy. Upon subcutaneous administration of carboxydextran-coated SPIO suspension into the breast, the carboxydextran-coated SPIO particles flow into and accumulate in the sentinel lymph nodes, which can be detected using a specific probe via magnetic sensing.

**Synonyms:** - Carboxydextran-coated SPIO - Carboxydextran-coated Superparamagnetic IO - Carboxydextran-coated Superparamagnetic Iron Oxide - Magtrace