ANKS1B wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human ANKS1B wild-type allele is located in the vicinity of 12q23.1 and is approximately 1258 kb in length. This allele, which encodes ankyrin repeat and sterile alpha motif domain-containing protein 1B, may play a role in the modulation of nucleolar numbers and amyloid precursor protein processing. Overexpression of the gene is stimulated by a chromosomal translocation t(1;19)(q23;p13.3) resulting in fusions of the TFE3 and PBX1 genes that is associated with B lymphoblastic leukemia/lymphoma.

**Synonyms:** - AIDA - AIDA-1 - ANKS2 - Ankyrin Repeat and Sterile Alpha Motif Domain Containing 1B wt Allele - Cajalin 2 Gene - Cajalin-2 Gene - E2A/PBX1-Activated Gene in Pre-B Cells 1 Gene - EB-1 - EB1