Genistein-based BIO 300

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A formulation containing synthetic genistein, a soy-derived isoflavone and phytoestrogen, with potential radioprotective, inflammatory modulating, immunomodulating and antioxidant activities. Upon administration of genistein-based BIO 300, genistein binds to and activates estrogen receptor beta (ERb), which results in the suppression of certain genes, such as nuclear factor-kappa B (NF-kB), cyclooxygenase-2 (COX-2) and tumor necrosis factor-alpha (TNF-alpha). This reduces cellular proliferation, stimulates cell cycle checkpoints, increases DNA repair, and enhances radioresistance when exposed to radiation. In addition, by repressing NF-kB, BIO 300 may attenuate certain radiation-induced pro-inflammatory markers and profibrotic mediators, such as interleukin-1beta (IL-1b), IL-6, IL-8, thereby mitigating the radiation-induced inflammatory response, and protects normal lung tissue and other tissues. Genistein also arrests hematopoietic stem cells at the G2/M phase and thereby reducing the harmful effects of irradiation on these cells. Genistein's antioxidant activities allow for scavenging of reactive oxygen species (ROS), thereby further protecting against cellular oxidative damage. Altogether, genistein may be able to mitigate radiation-induced cellular damage and may reduce or prevent radiation-induced acute myeloid injury, radiation-induced lung injury, and may reduce pulmonary edema, congestion, pneumonitis, and fibrosis. BIO 300 may also prevent viral infection-mediated inflammatory pulmonary injury.

**Synonyms:** - BIO 300 - BIO-300 - BIO300