PARG Inhibitor FORX-428

**Semantic type:** Pharmacologic Substance

**Definition:** An orally bioavailable small molecule inhibitor of poly (ADP-Ribose) (PAR) glycohydrolase (PARG), with potential antineoplastic activity. Upon oral administration, PARG inhibitor FORX-428 targets, reversibly binds to and inhibits the activity of PARG, thereby inhibiting the hydrolysis of PAR chains by PARG. This attenuates DNA repair and induces mitotic arrest, resulting in the apoptosis of cancer cells. PARG, the only enzyme responsible for hydrolyzing PAR chains produced by poly (ADP-ribose) polymerase (PARP) 1, plays a key role in the resolution of PARP 1/2-dependent DNA damage repair.

**Synonyms:** - FORX 428 - FORX-428 - FORX428