Hereditary Diffuse Gastric Cancer Syndrome

**Semantic type:** Disease or Syndrome

**Definition:** A rare autosomal dominant inherited syndrome caused by CDH1 and rarely CTNNA1 gene mutations. Affected individuals are at high risk of developing gastric diffuse adenocarcinoma and breast lobular carcinoma.

**Synonyms:** - HDGC Syndrome - Hereditary Diffuse Gastric Adenocarcinoma Syndrome - Hereditary Diffuse Gastric Carcinoma Syndrome - Hereditary Gastric Diffuse Adenocarcinoma Syndrome