Paramedullary Disease in Multiple Myeloma

**Semantic type:** Finding

**Definition:** Infiltration of soft tissue adjacent to cortical bone by malignant (clonal) plasma cells in patients with history of multiple myeloma. Unlike extramedullary disease in multiple myeloma, which is detached from bone, paramedullary disease in multiple myeloma develops via disruption of cortical bone and grows into adjacent tissue.

**Synonyms:** - PMD Multiple Myeloma