Core Binding Factor Transcription Complex Disruption

**Semantic type:** Laboratory or Test Result

**Definition:** A finding indicating the disruption of the core binding factor (CBF) transcription complex and dysregulation of CBF complex activity. It is often caused by chromosomal rearrangements involving either the RUNX1 or CBFB genes, which are associated with the development of acute myeloid leukemias.

**Synonyms:** - CBF Transcription Complex Disruption