NIH Consensus Response Criteria for Chronic GVHD Severity Score

**Semantic type:** Intellectual Product

**Definition:** A global score for chronic graft-versus-host disease using the NIH Consensus Response Criteria for Chronic Graft-versus-Host Disease (GVHD). Eight organs or sites (skin, mouth, eyes, gastrointestinal tract, liver, lungs, joint and fascia, and genital tract) are considered for calculating the global score. Elements include both the number of organs or sites involved and the severity score within each affected organ or site. Performance status scoring is not incorporated into the global scoring system. In skin: the higher of the 2 scores is used for calculating global severity. In lung: forced expiratory volume in 1 second (FEV1) is used instead of clinical score for calculating global severity. If the entire abnormality in an organ is noted to be unequivocally explained by a non-GVHD documented cause, that organ is not included for calculation of the global severity. If the abnormality in an organ is attributed to multifactorial causes (GVHD plus other causes) the scored organ will be used for calculation of the global severity regardless of the contributing causes (no downgrading of organ severity score).

**Synonyms:** - NIH Global Chronic GVHD Severity Score