Aminoglutethimide

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A synthetic derivative of the sedative and anticonvulsant glutethimide with anti-steroid properties. Originally used as an anticonvulsant, aminoglutethimide also blocks adrenal steroidogenesis by inhibiting the enzymatic conversion of cholesterol to pregnenolone. In addition, this agent blocks the peripheral aromatization of androgenic precursors to estrogens. Aminoglutethimide does not suppress ovarian estrogen production.

**Synonyms:** - 2-(p-Aminophenyl)-2-ethylglutarimide - 2-(p-Aminophenyl)-2-ethylglutarimide - 3-(4-Aminophenyl)-3-ethyl-2,6-piperidinedione - 3-Ethyl-3-(p-aminophenyl)-2,6-dioxopiperidine - AMINOGLUTETHIMIDE - Aminoblastin - BA-16038 - Ba-16038 - Cytadren - Elipten - Elipten - Mamomit - Orimenten - Orimeten - Orimetene - Rodazol - alpha-(4-Aminophenyl)-alpha-ethylglutarimide - aminoglutethimide