MUC-1 Antigen

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor

**Definition:** MUC-1 antigen is a mammary-type apomucin, a high molecular weight transmembrane glycoprotein, of which the extracellular domain is formed by a repeating 20 amino acid sequence (in tandem) with a high content of serine and threonine on which are O-linked carbohydrate chains. MUC-1 synthesis and secretion are features of glandular epithelial tissues; MUC-1 is overexpressed in lactating breast and in breast, ovary, lung, and prostate malignancies.

**Synonyms:** - CA15-3 Antigen - Cancer Antigen 15-3 - DF3 Antigen - Episialin - MAM-6 - MUC-1 - MUC-1 - Mucin Antigen - Mucin Peptide MUC-1 - Polymorphic Epithelial Mucin - Sialylated MUC-1 - mucin/peptide