Monoclonal Antibody A1G4 Anti-Idiotype Vaccine

**Semantic type:** Immunologic Factor|Pharmacologic Substance

**Definition:** An anti-idiotypic (anti-Id) rat monoclonal antibody (MoAb) that mimics the disialoganglioside GD2, a cancer-associated antigen present on melanoma, small cell lung cancer, sarcoma, neuroblastoma, and other malignancies. GD2 is a highly expressed glycosphingolipid by melanoma and other neuroectodermal tumors with only minimal expression on normal tissues. Vaccination with anti-Id A1G4 MoAb may elicit cellular and humoral immune responses against GD2 expression tumor cells.

**Synonyms:** - A1G4 anti-idiotype monoclonal antibody vaccine