Arzoxifene Hydrochloride

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** The hydrochloride salt of arzoxifene, a synthetic aromatic derivative with anti-estrogenic properties. Arzoxifene binds to estrogen receptors as a mixed estrogen agonist/antagonist. In comparison to other selective estrogen receptor modulators (SERMs), arzoxifene exhibits greater bioavailability and higher anti-estrogenic potency in the breast than raloxifene; it exhibits reduced estrogenicity in the uterus compared with either tamoxifen or raloxifene. This agent may have beneficial effects on bone and the cardiovascular system.

**Synonyms:** - 2-(4-Methoxyphenyl)-3-[4-[2-(1-piperidinyl)ethoxy]phenoxy]benzo[b]thiophene-6-ol hydrochloride - ARZOXIFENE HYDROCHLORIDE - Arzoxifene.HCl - Arzoxifenehydrochloride - LY353381 Hydrochloride - LY353381 hydrochloride - LY353381.HCL - LY353381.HCl - SERM-3 - SERM-3 - SERM3 - arzoxifene hydrochloride