Contusugene Ladenovec

**Semantic type:** Pharmacologic Substance|Virus

**Definition:** A replication-defective adenoviral-CMV vector that encodes a wild-type p53 gene. Contusugene ladenovec induces tumor cells that have been transfected with the vector to produce wild-type p53, a tumor suppressor gene that is deleted or mutated in a significant number of cancers. In transfected tumor cells, the wild-type p-53 gene product exerts an antitumor effect by blocking cell cycle progression at the G1/S regulation point, activating DNA repair proteins in the presence of DNA damage, and initiating apoptosis when DNA damage is irreparable. (NCI04)

**Synonyms:** - Ad-p53 - Ad5CMV p53 Gene - Adeno-p53 - Adenovirus p53 - Advexin - CONTUSUGENE LADENOVEC - INGN 201 - INGN-201 - INGN201 - RPR/INGN-201 - p53 Gene, Ad5CMV