Promegapoietin

**Semantic type:** Amino Acid, Peptide, or Protein|Pharmacologic Substance

**Definition:** Any one of the family of genetically engineered chimeric molecules with strong activity in promoting megakaryocyte development. Promegapoietin consists of a truncated or modified interleukin-3 (IL-3) peptide, via a hinge peptide sequence from IgG, linked to multiple repeats of modified thrombopoietin (c-Mpl ligand). This agent is capable of activating megakaryocyte progenitor cells into producing platelets mediated through either IL-3 receptor or Mpl receptor.

**Synonyms:** - SC 71858 - promegapoietin