Vadimezan

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A fused tricyclic analogue of flavone acetic acid with potential antineoplastic activity. Vadimezan induces the cytokines tumor necrosis alpha (TNF-alpha), serotonin and nitric oxide, resulting in hemorrhagic necrosis and a decrease in angiogenesis. This agent also stimulates the anti-tumor activity of tumor-associated macrophages.

**Synonyms:** - 5,6-Dimethylxanthenone-4-Acetic Acid - 5,6-MexXAA - AS 1404 - AS A404 - AS-1404 - AS-A404 - AS1404 - ASA404 - DMXAA - Dimethyloxoxanthene Acetic Acid - Dimethylxanthenone Acetic Acid - VADIMEZAN - dimethylxanthenone acetic acid