AFP Gene Hepatocellular Carcinoma Vaccine

**Semantic type:** Immunologic Factor|Pharmacologic Substance

**Definition:** A cancer vaccine composed of naked plasmid DNA of the gene for the tumor-associated antigen alpha-fetoprotein (AFP), a macromolecule that acts as a specific immunologic target for hepatocellular carcinoma. This agent exerts an antitumor effect by inducing cytotoxic T-lymphocytes to attack AFP-expressing tumor cells. (NCI04)

**Synonyms:** - vaccine, AFP gene hepatocellular carcinoma