Allogeneic GM-CSF-secreting Lethally Irradiated Prostate Cancer Vaccine

**Semantic type:** Cell|Immunologic Factor|Pharmacologic Substance

**Definition:** An allogeneic whole cell vaccine expressing human granulocyte macrophage-colony stimulating factor (GM-CSF) with potential antineoplastic activity. Tumor cells from prostate cancer patients are harvested and then genetically modified to secrete GM-CSF, an immune stimulatory growth factor that plays a key role in stimulating the body's immune responses against tumor cells. Because the vaccine is derived from allogenic cells, it has demonstrated a favorable side effect profile than other approaches of delivering long-lasting GM-CSF.

**Synonyms:** - Allogeneic GM-CSF Prostate Cancer Vaccine - Allogeneic Prostate Cancer Vaccine, GM- CSF Gene Transduced - Allogenic Prostate GVAX - GM-CSF Gene Transduced Allogeneic Prostate Cancer Vaccine - GVAX Allogeneic Prostate Cancer Vaccine - GVAX Allogenic Prostate Cancer Vaccine - GVAX Prostate - GVAX Prostate Cancer Vaccine - Prostate Cancer Vaccine, GM-CSF Gene Transduced - Prostate Cancer Vaccine, GVAX