Human Papillomavirus 16 E7 Peptide/Padre 965.10

**Semantic type:** Pharmacologic Substance

**Definition:** A synthetic agent derived from human papillomavirus (HPV) E7 nuclear protein which is used to produce vaccines against HPV infection and HPV-related neoplasms. HPV E7 oncogenic protein binds the retinoblastoma tumor suppressor protein, pRB, as well as a number of other cellular proteins, and serves as a transcriptional activator. This protein is important in the induction and maintenance of cellular transformation and is co-expressed in the majority of HPV-containing carcinomas. PADRE(R) is a proprietary family of molecules that enhances the immune systems response against an administered immunogen such as the HPV E7 nuclear protein. (NCI04)

**Synonyms:** - HPV16 E7/PADRE 965.10 - Lipidated HPV-16 E7/Padre-965.10