Tucotuzumab Celmoleukin

**Semantic type:** Amino Acid, Peptide, or Protein|Pharmacologic Substance

**Definition:** A recombinant fusion protein comprised of a human monoclonal antibody directed against the epithelial cell adhesion molecule (EpCAM or KS) linked to an active interleukin-2 (IL2) molecule with potential antineoplastic activity. Tucotuzumab Celmoleukin recognizes and binds to EpCAM, a cell surface epithelial protein that is expressed on a wide variety of cancer cells, thereby concentrating IL2 in EpCAM-expressing tumor tissue. Subsequently, the localized IL2 moiety of the fusion protein may stimulate a cytotoxic T-cell antitumor immune response.

**Synonyms:** - EMD 273066 - EMD-273066 - KSA-IL-2 - KSA-Interleukin-2 Fusion Protein - KSA-interleukin-2 - TUCOTUZUMAB CELMOLEUKIN - huKS-IL2 Fusion Protein