MVF-HER-2(628-647)-CRL 1005 Vaccine

**Semantic type:** Immunologic Factor|Pharmacologic Substance

**Definition:** A chimeric peptide immunogen of human epidermal growth factor-2 (HER-2) with antineoplastic property. HER-2 protein is a receptor tyrosine kinase and a tumor-associated antigen (TAA) that is overexpressed in a variety of cancers. MVF-HER-2(628-647)-CRL 1005 vaccine, coated with poloxamer CRL-1005 to form microparticles, consists of a mutated HER-2 B-cell epitope, HER-2(628-647), and a promiscuous T cell epitope (amino acid sequence 288-302) of the measles virus fusion protein (MVF). Vaccination with this immunogen may stimulate the host immune response to mount a cytotoxic T-lymphocyte response against tumor cells that overexpress the HER2 protein, resulting in tumor cell lysis.