T-Cell Receptor Delta Locus

**Semantic type:** Gene or Genome

**Definition:** This region represents the germline organization of the T cell receptordelta locus. The delta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several D and J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. (from LocusLink)

**Synonyms:** - T Cell Receptor Delta Locus - T-Cell Receptor Delta Gene - TCRD - TRD - TRD - TRD