Fibrin Sealant

**Semantic type:** Pharmacologic Substance

**Definition:** A plasma-derived fibrin biomatrix preparation consisting of two separate solutions that are combined on application. The sealer protein solution contains clottable human fibrinogen and bovine aprotinin, a fibrinolysis inhibitor; the thrombin solution contains human thrombin and calcium chloride. When the solutions are combined, a clot is formed, reproducing the final stages of the coagulation cascade.

**Synonyms:** - Artiss - Beriplast P - Beriplast P - TISSEEL - TISSEEL VH Kit - fibrin sealant