Lapatinib

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A synthetic, orally-active quinazoline with potential antineoplastic properties. Lapatinib reversibly blocks phosphorylation of the epidermal growth factor receptor (EGFR), ErbB2, and the Erk-1 and-2 and AKT kinases; it also inhibits cyclin D protein levels in human tumor cell lines and xenografts. EGFR and ErbB2 have been implicated in the growth of various tumor types.

**Synonyms:** - GSK572016 - GW 2016 - GW 572016 - GW-572016 - GW2016 - GW572016 - GW572016 - LAPATINIB - lapatinib