Zileuton

**Semantic type:** Pharmacologic Substance

**Definition:** A synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which catalyzes the formation of leukotrienes from arachidonic acid; causes bronchodilation; decreases bronchial mucous secretion and edema; and may prevent or decrease the symptoms of asthma. (NCI04)

**Synonyms:** - (+-)-N-Hydroxy-N-(1-benzo[b]thien-2-ylethyl)-urea - N-(1-Benzo[b]thien-2-ylethyl)-N-hydroxyurea - ZILEUTON - Zyflo - zileuton