Endothelin Receptor Type A Antagonist YM598

**Semantic type:** Pharmacologic Substance

**Definition:** An orally active synthetic substituted phenylethenesulfonamide. As a selective endothelin A receptor antagonist, YM598 inhibits endothelin-mediated mechanisms involved in tumor cell growth and progression, angiogenesis, and metastasis. (NCI04)

**Synonyms:** - NEBENTAN POTASSIUM - Potassium (E)-N-[6-methoxy-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-phenylenthene Sulfonamidate - YM598 - YM598