Sinusoidal Obstruction Syndrome

**Semantic type:** Disease or Syndrome

**Definition:** A disorder characterized by inflammation and damage of the hepatic sinusoidal endothelial cells of the hepatic venules that leads to venular occlusion and hepatocellular necrosis. It is most often a conditioning-related toxicity that results as a complication of hematopoietic stem cell transplantation (HSCT). It has also been described in populations of individuals who have ingested pyrrolizidine plant alkaloids. The clinical signs and symptoms include hyperbilirubinemia, hepatomegaly, and fluid retention.

**Synonyms:** - Hepatic Veno-Occlusive Disease - Hepatic veno-occlusive disease - Liver Veno-Occlusive Disease - hepatic veno-occlusive disease