Glycinamide Ribonucleotide Formyltransferase Inhibitor

**Semantic type:** Chemical Viewed Functionally

**Definition:** Any substance that inhibits glycinamide ribonucleotide formyltransferase, the first folate dependent enzyme in de novo purine synthesis. Inhibition of glycinamide ribonucleotide formyltransferase causes purine depletion and results in inhibition of DNA synthesis and cell cycle arrest.

**Synonyms:** - glycinamide ribonucleotide formyltransferase inhibitor