c-raf Antisense Oligonucleotide ISIS 5132

**Semantic type:** Nucleic Acid, Nucleoside, or Nucleotide|Pharmacologic Substance

**Definition:** A synthetic, 20-base antisense oligodeoxynucleotide that hybridizes to c-raf kinase messenger RNA. ISIS 5132 has been shown to specifically suppress Raf-1 expression both in vitro and in vivo. Raf-1 serine/threonine kinase functions as a critical effector of Ras-mediated signal transduction; constitutive activation of this pathway directly contributes to malignant transformation. (NCI04)

**Synonyms:** - CGP 69846A - CGP69846A - ISIS 5132 - ISIS 5132 - ISIS 5132/CGP69846A - ISIS-5132 - ISIS-5132 - RAF-IK Antisense ODN - c-RAF Antisense