Malignant Lymphoma, Large Cell, Cleaved and Non-Cleaved

**Semantic type:** Neoplastic Process

**Definition:** Antiquated term describing follicular (nodular) or diffuse non-Hodgkin lymphomas that are composed of a mixture of large cells: large cleaved cells, with irregular nuclei without visible nucleoli; and large non-cleaved cells (centroblasts), having a rounder nucleus with two to three small, peripherally placed nucleoli and a small amount of basophilic cytoplasm. The follicular variants represent mature B-cell lymphomas, whereas the diffuse variants can be either mature B- or mature T-cell lymphomas.