Vandetanib

**Semantic type:** Pharmacologic Substance

**Definition:** An orally bioavailable 4-anilinoquinazoline. Vandetanib selectively inhibits the tyrosine kinase activity of vascular endothelial growth factor receptor 2 (VEGFR2), thereby blocking VEGF-stimulated endothelial cell proliferation and migration and reducing tumor vessel permeability. This agent also blocks the tyrosine kinase activity of epidermal growth factor receptor (EGFR), a receptor tyrosine kinase that mediates tumor cell proliferation and migration and angiogenesis.

**Synonyms:** - AZD 6474 - AZD-6474 - AZD6474 - Caprelsa - Lucivand - VANDETANIB - ZD-6474 - ZD6474 - ZD6474 - Zactima - Zactima - vandetanib