EWS/FLI 1 Type 2

**Semantic type:** Nucleic Acid, Nucleoside, or Nucleotide|Pharmacologic Substance

**Definition:** The more potent transcription activator allele of a transforming chimeric gene resulting from a t(11;22) translocation that is found frequently in Ewing's sarcoma and primitive neuroectodermal tumor (PNET). EWS-FLI1 type 2 encodes the mTOR protein, a central regulator of translation and cell proliferation that activates the mitogen-activated protein kinase (MAPK) signaling system, resulting in neoplastic transformation. Antisense oligonucleotides that target EWS-FLI1 type 2 have been used investigationally to arrest cancer cells in the G1 phase of the cell cycle. (NCI04)

**Synonyms:** - EF-2 - EF-2 (EWS-FLI 1 TYPE 2) - EWS/FLI 1 (type 2) - EWS/FLI 1 Type 2 Fusion Gene