Proteinase 3:PR1 Peptide

**Semantic type:** Amino Acid, Peptide, or Protein|Pharmacologic Substance

**Definition:** A synthetic HLA-A2-restricted nonapeptide derived from proteinase 3 with potential use in cancer immunotherapy. Cytotoxic T lymphocytes (CTL) primed with proteinase 3 PR1 peptide attack leukemic cells that express proteinase 3 aberrantly. Proteinase 3 is a serine proteinase that activates progelatinase A and is involved in metastasis and angiogenesis. (NCI04)