PAX3/FKHR

**Semantic type:** Gene or Genome|Pharmacologic Substance

**Definition:** An antisense oligonucleotide targeting mRNA of the chimeric PAX3/FKHR fusion gene, an oncogenic transcriptional activator found in rhabdomyosarcomas. PAX3/FKHR antisense oligonucleotide down-regulates protein production and induces apoptosis in cells expressing the PAX3/FKHR fusion gene. (NCI04)

**Synonyms:** - PAX3/FKHR Fusion Gene - PXFK - PXFK