Recombinant Fowlpox-Tyrosinase Vaccine

**Semantic type:** Immunologic Factor|Pharmacologic Substance|Virus

**Definition:** A recombinant fowlpox virus vaccine with potential antineoplastic activity. Binding to the melanoma antigen tyrosinase, recombinant fowlpox-tyrosinase vaccine generates cellular immune responses against melanoma cells expressing the tyrosinase antigen; this effect is enhanced by the co-administration of interleukin 2 (IL-2). Fowlpox virus is an attractive vector because its genome is easy to manipulate and it is replication incompetent in mammalian cells.

**Synonyms:** - Tyrosinase-Fowl Pox - rF-TYR - rF-TYR vaccine