Recombinant Fowlpox-B7.1

**Semantic type:** Pharmacologic Substance|Virus

**Definition:** A recombinant fowlpox virus vector encoding human B7.1 (CD80 antigen), a T-cell costimulatory molecule. Recombinant Fowlpox-B7.1 may be used as a vaccine vector; incorporating the B7-1 gene into this vector may enhance the presentation of fowlpox virus vector-encoded tumor antigens to antigen presenting cells (APC) and activate cytotoxic T-cells against tumor antigen-expressing tumors. The fowlpox vector is easily manipulated and does not multiply in human tissues. (NCI04)

**Synonyms:** - rF-B7.1