J5 Antiserum

**Semantic type:** Immunologic Factor|Pharmacologic Substance

**Definition:** An antiserum raised against endotoxins of Escherichia coli J5 strain with potential antibacterial activity. J5 antiserum reacts with lipid A, the key endotoxic component of the lipopolysaccharides (LPS), found mostly in gram-negative bacteria. By binding to endotoxins, J5 antiserum prevents the initiation of a cascade of events in host cells, including the production of pro-inflammatory cytokines that eventually leads to the sepsis syndrome.

**Synonyms:** - Antiserum to Endotoxin Core