M-Phase Promoting Factor

**Semantic type:** Amino Acid, Peptide, or Protein|Enzyme

**Definition:** M Phase-Promoting Factor is a protein kinase complex that drives both the mitotic and meiotic cycles in all eukaryotic organisms. In meiosis it induces immature oocytes to undergo meiotic maturation. In mitosis it has a role in the G2/M phase transition. Once activated by CYCLINS; MPF directly phosphorylates some of the proteins involved in nuclear envelope breakdown, chromosome condensation, spindle assembly, and the degradation of cyclins. The catalytic subunit of MPF is PROTEIN P34CDC2.

**Synonyms:** - M Phase-Promoting Factor - M-Phase-Promoting Factor - MPF - Maturation Promoting Factor - Maturation-Promoting Factor - Mitosis Promoting Factor - Mitosis-Promoting Factor