Primary Myelofibrosis

**Semantic type:** Neoplastic Process

**Definition:** A chronic myeloproliferative neoplasm characterized by bone marrow fibrosis, proliferation of atypical megakaryocytes and granulocytes in the bone marrow, anemia, splenomegaly, and extramedullary hematopoiesis. (WHO, 2001)

**Synonyms:** - AMM - Agnogenic Myeloid Metaplasia - Agnogenic myeloid metaplasia - Idiopathic Bone Marrow Fibrosis - Idiopathic Myelofibrosis - Myelosclerosis with Myeloid Metaplasia - Myelosclerosis with myeloid metaplasia - PMF - Primary myelofibrosis - agnogenic myeloid metaplasia - idiopathic myelofibrosis - myelosclerosis with myeloid metaplasia