Recombinant 70-kD Heat-Shock Protein

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor

**Definition:** A recombinant peptide that is chemically identical to or similar to the endogenous 70-kD heat shock protein (HSP70). HSP70 is a molecular chaperone that prevents physiologic stress-induced cell death by inhibiting both caspase-dependent and caspase-independent apoptosis. Because this peptide is often overexpressed in tumor cells, autologous vaccination with HSP70 derived from tumor cells may stimulate the host immune system to mount a tumoricidal cytotoxic T lymphocyte (CTL) response. (NCI04)

**Synonyms:** - 70-kD Heat-Shock Protein - HSP70 - Heat Shock Protein 70