Baclofen

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A synthetic chlorophenyl-butanoic acid derivative used to treat spasms due to spinal cord damage and multiple sclerosis, muscle-relaxing Baclofen acts as a gamma-aminobutyric acid (GABA) agonist specific for GABA-B receptors. It acts at spinal and supraspinal sites, reducing excitatory transmission. (NCI04)

**Synonyms:** - 4-Amino-3-(4-chlorophenyl)-butanoic Acid - BA34647 - BACLOFEN - Gablofen - Kemstro - Kemstro - Lioresal - Lioresal - baclofen - beta-(Aminomethyl)-4-chlorobenzenepropanoic Acid