Penicillin G Sodium

**Semantic type:** Antibiotic|Pharmacologic Substance

**Definition:** The sodium salt form of benzylpenicillin, a semi-synthetic, broad-spectrum penicillin antibiotic with bactericidal activity. Benzylpenicillin sodium binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.

**Synonyms:** - 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic Acid, 3,3-dimethyl-7-oxo-6-((phenylacetyl)amino)-,(2S-(2alpha,5alpha,6beta))-, Monosodium Salt - Benzylpenicillin Sodium - Benzylpenicillin Sodium Salt - Novocillin - PENICILLIN G SODIUM - Penicillin - Penilaryn - Sugracillin Sodium Salt - Veticillin