Bumetanide

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A potent sulfamoylanthranilic acid derivative belonging to the class of loop diuretics. In the brain, bumetanide may prevent seizures in neonates by blocking the bumetanide-sensitive sodium-potassium-chloride cotransporter (NKCC1), thereby inhibiting chloride uptake thus, decreasing the internal chloride concentration in neurons and may block the excitatory effect of GABA in neonates.

**Synonyms:** - BUMETANIDE - Bumex - Burinex - Edemex