Chelate-Monoclonal Antibody B72.3

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** An immunoconjugate of a murine monoclonal antibody CYT-099 (B72.3), with specificity for tumor-associated glycoprotein-72 (TAG-72), a human pancarcinoma antigen, chemically-linked to a linker-chelator molecule, glycyl-tyrosyl-(N,N-diethylenetriaminepentaacetic acid)-lysine hydrochloride (GYK-DTPA-HCl). This agent is reacted in the nuclear pharmacy with Indium-111 radioisotope to form the active radioimmune conjugate, which is injected for radioimaging of tumors expressing TAG-72.