Chimeric Monoclonal Antibody B72.3

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** A synthetic chimeric molecule in which a mouse monoclonal antibody variable region directed against the tumor-associated glycoprotein 72 (TAG-72) is fused to a human antibody constant region. This agent reacts to most human adenocarcinomas (colorectal, gastric, pancreatic, ovarian, endometrial, mammary) but has weak or undetectable reactivity to most normal tissues. (NCI04)

**Synonyms:** - Chimeric B72.3